Vaginal epithelium maturation was stimulated by DHEA administration in 8 of 10 women who had a maturation value of zero at the onset of therapy, whereas a stimulatory effect was also seen in all three women who had an intermediate vaginal maturation index before therapy. The estrogenic effect of DHEA observed in the vagina was not observed in the endometrium, which remained atrophic in all women. Most interesting, the bone mineral density significantly increased at the hip from 0.
View All. Listen to Holly Thacker, M. I have severe vaginal dryness and atrophy, continuous UTIs and pain in the urogenital area.
Clinicians caring for menopausal women are familiar with the genitourinary syndrome of menopause GSMpreviously referred to as vulvovaginal atrophy, a progressive condition that impairs sexual function and quality of life. Declines in estrogen associated with menopause play a central role in the pathophysiology of GSM. The occurrence of symptomatic GSM in premenopausal women with hypoestrogenemic states, including lactation and use of GnRH agonists, underscores the central role estrogen plays in maintaining normal vaginal function. Over-the-counter OTC vaginal lubricants used with sexual activity and vaginal moisturizers used on a routine basis several times per week can provide some relief from symptoms of GSM.
Vaginal dehydroepiandrosterone DHEA may improve sexual function, without negative systemic effects, in women with breast and gynecologic cancer with vaginal and sexual-related complaints. Breast and gynecologic cancer patients can experience a range of symptoms associated with sexual dysfunction, among them vaginal dryness and dyspareunia. Current Interventions The vagina is highly regulated by estrogen.
It is being touted by the manufacturer and some doctors especially those studying it and consulting for the company as an alternative to estrogen. But is it? And since this often comes up just a reminder that I take no money from pharma.
Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. Prasterone is a manmade form of a hormone called dehydroepiandrosterone DHEA.
Study record managers: refer to the Data Element Definitions if submitting registration or results information. For this purpose, endometrial biopsies were performed at screening and at the end of the study 52 weeks or at discontinuation visit for women who were exposed to intravaginal DHEA prasterone for at least 12 weeks. Only the end-of-study data are presented.
Reuters Health - A vaginal suppository containing the hormone known as DHEA is a good alternative to estrogen for treating vaginal issues related to menopause, according to a new trial. Pain during sex and vaginal dryness improved more in postmenopausal women taking the daily suppositories than in women using placebos, researchers report. Gynecologists said the overall vaginal health of those taking the suppositories improved more, too.
The formulation could provide women who cannot or do not wish to use intravaginal estrogen with an effective vaginal alternative for easing vaginal symptoms and pain with sex after menopause. Without hormonal treatment after menopause, vaginal tissues atrophy, the lining thins and secretes less and less fluid, and the pH becomes more alkaline, which leads to discomfort with sex as well as increased susceptibility to vaginal infections and urinary problems for many women. But compared with the women who used a placebo, the women who used the daily 0.